Publication: Population pharmacokinetic analyses of regorafenib and capecitabine in patients with locally advanced rectal cancer (SAKK 41/16 RECAP)
Population pharmacokinetic analyses of regorafenib and capecitabine in patients with locally advanced rectal cancer (SAKK 41/16 RECAP)
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Schmulenson, E., Bovet, C., Theurillat, R., Decosterd, L. A., Largiadèr, C. R., Prost, J.-C., Csajka, C., Bärtschi, D., Guckenberger, M., von Moos, R., Bastian, S., Joerger, M., & Jaehde, U. (2022). Population pharmacokinetic analyses of regorafenib and capecitabine in patients with locally advanced rectal cancer (SAKK 41/16 RECAP). British Journal of Clinical Pharmacology, 88(12), 5336–5347. https://doi.org/10.1111/bcp.15461
Abstract
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Abstract
Aims: Locally advanced rectal cancer (LARC) is an area of unmet medical need with one third of patients dying from their disease. With response to neoadjuvant chemo-radiotherapy being a major prognostic factor, trial SAKK 41/16 assessed potential benefits of adding regorafenib to capecitabine-amplified neoadjuvant radiotherapy in LARC patients.
Methods: Patients received regorafenib at three dose levels (40/80/120 mg once daily) combined with capecitabine 825 mg/m2 bidaily and local radiotherapy. We developed population pharmacokinet
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Creators (Authors)
- Schmulenson, Eduard
- Bovet, Cédric
- Theurillat, Regula
- Decosterd, Laurent Arthur
- Largiadèr, Carlo R
- Prost, Jean-Christophe
- Csajka, Chantal
- Bärtschi, Daniela
- Guckenberger, Matthias
- von Moos, Roger
- Bastian, Sara
- Joerger, Markus
- Jaehde, Ulrich
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Citations
Schmulenson, E., Bovet, C., Theurillat, R., Decosterd, L. A., Largiadèr, C. R., Prost, J.-C., Csajka, C., Bärtschi, D., Guckenberger, M., von Moos, R., Bastian, S., Joerger, M., & Jaehde, U. (2022). Population pharmacokinetic analyses of regorafenib and capecitabine in patients with locally advanced rectal cancer (SAKK 41/16 RECAP). British Journal of Clinical Pharmacology, 88(12), 5336–5347. https://doi.org/10.1111/bcp.15461
