Publication: DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells
DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells
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Boleslavska, B., Oravetzova, A., Shukla, K., Nascakova, Z., Ibini, O. N., Hasanova, Z., Andrs, M., Kanagaraj, R., Dobrovolna, J., & Janscak, P. (2022). DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells. Nucleic Acids Research, 50(21), 12274–12290. https://doi.org/10.1093/nar/gkac1116
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R-loops are three-stranded nucleic acid structures composed of an RNA:DNA hybrid and displaced DNA strand. These structures can halt DNA replication when formed co-transcriptionally in the opposite orientation to replication fork progression. A recent study has shown that replication forks stalled by co-transcriptional R-loops can be restarted by a mechanism involving fork cleavage by MUS81 endonuclease, followed by ELL-dependent reactivation of transcription, and fork religation by the DNA ligase IV (LIG4)/XRCC4 complex. However, how
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Boleslavska, B., Oravetzova, A., Shukla, K., Nascakova, Z., Ibini, O. N., Hasanova, Z., Andrs, M., Kanagaraj, R., Dobrovolna, J., & Janscak, P. (2022). DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells. Nucleic Acids Research, 50(21), 12274–12290. https://doi.org/10.1093/nar/gkac1116
