Publication: Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies
Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies
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Waltenspühl, Y., Ehrenmann, J., Klenk, C., & Plückthun, A. (2021). Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies. Molecules, 26(5), 1465. https://doi.org/10.3390/molecules26051465
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Abstract
Membrane proteins such as G protein-coupled receptors (GPCRs) exert fundamental biological functions and are involved in a multitude of physiological responses, making these receptors ideal drug targets. Drug discovery programs targeting GPCRs have been greatly facilitated by the emergence of high-resolution structures and the resulting opportunities to identify new chemical entities through structure-based drug design. To enable the determination of high-resolution structures of GPCRs, most receptors have to be engineered to overcome
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- Waltenspühl, Yann
- Ehrenmann, Janosch
- Klenk, Christoph
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Waltenspühl, Y., Ehrenmann, J., Klenk, C., & Plückthun, A. (2021). Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies. Molecules, 26(5), 1465. https://doi.org/10.3390/molecules26051465
