Publication: A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs
A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs
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Soneson, C., Love, M. I., Patro, R., Hussain, S., Malhotra, D., & Robinson, M. D. (2019). A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs. Life Science Alliance, 2(1), e201800175. https://doi.org/10.26508/lsa.201800175
Abstract
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Abstract
Most methods for statistical analysis of RNA-seq data take a matrix of abundance estimates for some type of genomic features as their input, and consequently the quality of any obtained results is directly dependent on the quality of these abundances. Here, we present the junction coverage compatibility score, which provides a way to evaluate the reliability of transcript-level abundance estimates and the accuracy of transcript annotation catalogs. It works by comparing the observed number of reads spanning each annotated splice junct
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- Soneson, Charlotte
- Love, Michael I
- Patro, Rob
- Hussain, Shobbir
- Malhotra, Dheeraj
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Citations
Soneson, C., Love, M. I., Patro, R., Hussain, S., Malhotra, D., & Robinson, M. D. (2019). A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs. Life Science Alliance, 2(1), e201800175. https://doi.org/10.26508/lsa.201800175
