A prospective cohort study about the effect of repeated living high and working higher on cerebral autoregulation in unacclimatized lowlanders

Graf, Laura C; Hartmann, Sara E; Lichtblau, Mona; Muralt, Lara; Bader, Patrick Raphael; Lopez, Ivan; Rawling, Jean M; Ulrich, Silvia; Bloch, Konrad E; Poulin, Marc J; Furian, Michael

doi:10.1038/s41598-022-06270-z

Citations

Citation copied

Graf, L. C., Hartmann, S. E., Lichtblau, M., Muralt, L., Bader, P. R., Lopez, I., Rawling, J. M., Ulrich, S., Bloch, K. E., Poulin, M. J., & Furian, M. (2022). A prospective cohort study about the effect of repeated living high and working higher on cerebral autoregulation in unacclimatized lowlanders. Scientific Reports, 12, 2472. https://doi.org/10.1038/s41598-022-06270-z

Abstract

Cerebral autoregulation (CA) is impaired during acute high-altitude (HA) exposure, however, effects of temporarily living high and working higher on CA require further investigation. In 18 healthy lowlanders (11 women), we hypothesized that the cerebral autoregulation index (ARI) assessed by the percentage change in middle cerebral artery peak blood velocity (Δ%MCAv)/percentage change in mean arterial blood pressure (Δ%MAP) induced by a sit-to-stand maneuver, is (i) reduced on Day1 at 5050 m compared to 520 m, (ii) is improved after 6