Publication: Anesthesia increases circulating glutamate in neurosurgical patients
Anesthesia increases circulating glutamate in neurosurgical patients
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Stover, J. F., & Kempski, O. S. (2005). Anesthesia increases circulating glutamate in neurosurgical patients. Acta Neurochirurgica, 147(8), 847–853. https://doi.org/10.1007/s00701-005-0562-y
Abstract
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BACKGROUND: The excitotoxic amino acid glutamate is known to aggravate pre-existing neuropathology. Since volatile anesthetics increase plasma amino acid levels, we investigated if the anesthetics isoflurane and propofol increase plasma and cerebrospinal fluid (CSF) glutamate in neurosurgical patients. METHODS: In discectomized patients (n = 15), plasma glutamate was determined at 30 minute intervals before and during isoflurane anesthesia. In craniotomized patients (n = 66), plasma glutamate was assessed during and up to 24 hours aft
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- Stover, J F
- Kempski, O S
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Stover, J. F., & Kempski, O. S. (2005). Anesthesia increases circulating glutamate in neurosurgical patients. Acta Neurochirurgica, 147(8), 847–853. https://doi.org/10.1007/s00701-005-0562-y
