Timing of Revascularization and Parenteral Antibiotic Treatment Associated with Therapeutic Failures in Ischemic Diabetic Foot Infections

Altmann, Dominique; Waibel, Felix W A; Forgo, Gabor; Grigorean, Alexandru; Lipsky, Benjamin A; Uçkay, Ilker; Schöni, Madlaina

doi:10.5167/uzh-235472

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Altmann, D., Waibel, F. W. A., Forgo, G., Grigorean, A., Lipsky, B. A., Uçkay, I., & Schöni, M. (2023). Timing of Revascularization and Parenteral Antibiotic Treatment Associated with Therapeutic Failures in Ischemic Diabetic Foot Infections. Antibiotics, 12(4), 685. https://doi.org/10.3390/antibiotics12040685

Abstract

For ischemic diabetic foot infections (DFIs), revascularization ideally occurs before surgery, while a parenteral antibiotic treatment could be more efficacious than oral agents. In our tertiary center, we investigated the effects of the sequence between revascularization and surgery (emphasizing the perioperative period of 2 weeks before and after surgery), and the influence of administering parenteral antibiotic therapy on the outcomes of DFIs. Among 838 ischemic DFIs with moderate-to-severe symptomatic peripheral arterial disease,