Publication: T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19
T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19
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Taeschler, P., Adamo, S., Deng, Y., Cervia, C., Zurbuchen, Y., Chevrier, S., Raeber, M. E., Hasler, S., Bächli, E., Rudiger, A., Stüssi-Helbling, M., Huber, L. C., Bodenmiller, B., Boyman, O., & Nilsson, J. (2022). T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19. Allergy, 77, 2468–2481. https://doi.org/10.1111/all.15372
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BACKGROUND T-cell lymphopenia and functional impairment is a hallmark of severe acute coronavirus disease 2019 (COVID-19). How T-cell numbers and function evolve at later timepoints after clinical recovery remains poorly investigated.
METHODS We prospectively enrolled and longitudinally sampled 173 individuals with asymptomatic to critical COVID-19 and analyzed phenotypic and functional characteristics of T cells using flow cytometry, 40-parameter mass cytometry, targeted proteomics, and functional assays.
RESULTS The extensive T-ce
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Taeschler, P., Adamo, S., Deng, Y., Cervia, C., Zurbuchen, Y., Chevrier, S., Raeber, M. E., Hasler, S., Bächli, E., Rudiger, A., Stüssi-Helbling, M., Huber, L. C., Bodenmiller, B., Boyman, O., & Nilsson, J. (2022). T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19. Allergy, 77, 2468–2481. https://doi.org/10.1111/all.15372
