Publication: A New Zebrafish Model for CACNA2D4-Dysfunction
A New Zebrafish Model for CACNA2D4-Dysfunction
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Schlegel, D. K., Glasauer, S. M. K., Mateos, J. M., Barmettler, G., Ziegler, U., & Neuhauss, S. C. F. (2019). A New Zebrafish Model for CACNA2D4-Dysfunction. Investigative Ophthalmology & Visual Science, 60(15), 5124–5135. https://doi.org/10.1167/iovs.19-26759
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Purpose: Mutations in CACNA2D4, encoding the α2δ4 subunit of retinal voltage-gated calcium channels (Cav), cause a rare type of retinal dysfunction in human, mainly affecting cone vision. Here, we investigate the role of CACNA2D4 in targeting of Cav, its influence on cone-mediated signal transmission, and the cellular and subcellular changes upon loss of α2δ4 by exploiting the advantages of the cone-dominant zebrafish as model system. Methods: We identified two zebrafish CACNA2D4 paralogs (cacna2d4a and cacna2d4b), analyzed their expr
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- Schlegel, Domino K
- Glasauer, Stella M K
- Barmettler, Gery
- Ziegler, Urs
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Schlegel, D. K., Glasauer, S. M. K., Mateos, J. M., Barmettler, G., Ziegler, U., & Neuhauss, S. C. F. (2019). A New Zebrafish Model for CACNA2D4-Dysfunction. Investigative Ophthalmology & Visual Science, 60(15), 5124–5135. https://doi.org/10.1167/iovs.19-26759
