Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage

Endo, T; Maekawa, F; Võikar, V; Haijima, A; Uemura, Y; Zhang, Y; Miyazaki, W; Suyama, S; Shimazaki, K; Wolfer, D P; Yada, T; Tohyama, C; Lipp, H P; Kakeyama, M

doi:10.1016/j.bbr.2011.02.037

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Endo, T., Maekawa, F., Võikar, V., Haijima, A., Uemura, Y., Zhang, Y., Miyazaki, W., Suyama, S., Shimazaki, K., Wolfer, D. P., Yada, T., Tohyama, C., Lipp, H. P., & Kakeyama, M. (2011). Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage. Behavioural Brain Research, 221(1), 172–181. https://doi.org/10.1016/j.bbr.2011.02.037

Abstract

There has been a long-standing need to develop efficient and standardized behavioral test methods for evaluating higher-order brain functions in mice. Here, we developed and validated a behavioral flexibility test in mice using IntelliCage, a fully automated behavioral analysis system for mice in a group-housed environment. We first developed a "behavioral sequencing task" in the IntelliCage that enables us to assess the learning ability of place discrimination and behavioral sequence for reward acquisition. In the serial reversal lea