Publication: Nogo-A antibodies enhance axonal repair and remyelination in neuro-inflammatory and demyelinating pathology
Nogo-A antibodies enhance axonal repair and remyelination in neuro-inflammatory and demyelinating pathology
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Ineichen, B. V., Kapitza, S., Bleul, C., Good, N., Plattner, P. S., Seyedsadr, M. S., Kaiser, J., Schneider, M. P., Zörner, B., Martin, R., Linnebank, M., & Schwab, M. E. (2017). Nogo-A antibodies enhance axonal repair and remyelination in neuro-inflammatory and demyelinating pathology. Acta Neuropathologica, 134, 423–440. https://doi.org/10.1007/s00401-017-1745-3
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Two hallmarks of chronic multiple sclerosis lesions are the absence of significant spontaneous remyelination and primary as well as secondary neurodegeneration. Both characteristics may be influenced by the presence of inhibitory factors preventing myelin and neuronal repair. We investigated the potential of antibodies against Nogo-A, a well-known inhibitory protein for neuronal growth and plasticity, to enhance neuronal regeneration and remyelination in two animal models of multiple sclerosis. We induced a targeted experimental autoi
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- Ineichen, Benjamin V
- Kapitza, Sandra
- Bleul, Christiane
- Good, Nicolas
- Plattner, Patricia S
- Seyedsadr, Maryam S
- Kaiser, Julia
- Schneider, Marc P
- Zörner, Björn
- Linnebank, Michael
- Schwab, Martin E
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Ineichen, B. V., Kapitza, S., Bleul, C., Good, N., Plattner, P. S., Seyedsadr, M. S., Kaiser, J., Schneider, M. P., Zörner, B., Martin, R., Linnebank, M., & Schwab, M. E. (2017). Nogo-A antibodies enhance axonal repair and remyelination in neuro-inflammatory and demyelinating pathology. Acta Neuropathologica, 134, 423–440. https://doi.org/10.1007/s00401-017-1745-3
