Publication: Design and Assembly of pH-Sensitive Lipidic Cubic Phase Matrices for Drug Release
Design and Assembly of pH-Sensitive Lipidic Cubic Phase Matrices for Drug Release
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Nazaruk, E., Szlęzak, M., Górecka, E., Bilewicz, R., Osornio, Y. M., Uebelhart, P., & Landau, E. M. (2014). Design and Assembly of pH-Sensitive Lipidic Cubic Phase Matrices for Drug Release. Langmuir, 30(5), 1383–1390. https://doi.org/10.1021/la403694e
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Bicontinuous lipidic cubic phases (LCPs) exhibit a combination of material properties that make them highly interesting for various biomaterial applications: they are nontoxic, biodegradable, optically transparent, thermodynamically stable in excess water, and can incorporate active molecules of virtually any polarity. Here we present a molecular system comprising host lipid, water, and designed lipidic additive, which form a structured, pH-sensitive lipidic matrix for hydrophilic as well as hydrophobic drug incorporation and release.
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- Nazaruk, Ewa
- Górecka, Ewa
- Bilewicz, Renata
- Osornio, Yazmin M
- Uebelhart, Peter
- Landau, Ehud M
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Nazaruk, E., Szlęzak, M., Górecka, E., Bilewicz, R., Osornio, Y. M., Uebelhart, P., & Landau, E. M. (2014). Design and Assembly of pH-Sensitive Lipidic Cubic Phase Matrices for Drug Release. Langmuir, 30(5), 1383–1390. https://doi.org/10.1021/la403694e