Publication: Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia
Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia
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Tokonami, N., Cheval, L., Monnay, I., Meurice, G., Loffing, J., Feraille, E., & Houillier, P. (2017). Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia. Journal of Physiology, 595(8), 2535–2550. https://doi.org/10.1113/JP273610
Abstract
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Abstract
Acute hypercalcaemia increases urinary sodium and water excretion; however, the underlying molecular mechanism remains unclear. Because vitamin D-induced hypercalcaemia increases the renal expression of endothelin (ET)-1, we hypothesized that ET-1 mediates the effects of hypercalcaemia on renal sodium and water handling. Hypercalcaemia was induced in 8-week-old, parathyroid hormone-supplemented, male mice by oral administration of dihydrotachysterol (DHT) for 3 days. DHT-treated mice became hypercalcaemic and displayed increased urina
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- Tokonami, Natsuko
- Cheval, Lydie
- Monnay, Isabelle
- Meurice, Guillaume
- Loffing, Johannes
- Feraille, Eric
- Houillier, Pascal
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Tokonami, N., Cheval, L., Monnay, I., Meurice, G., Loffing, J., Feraille, E., & Houillier, P. (2017). Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia. Journal of Physiology, 595(8), 2535–2550. https://doi.org/10.1113/JP273610