Publication: Transient activation of the HOG MAPK pathway regulates bimodal gene expression
Transient activation of the HOG MAPK pathway regulates bimodal gene expression
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Pelet, S., Rudolf, F., Nadal-Ribelles, M., de Nadal, E., Posas, F., & Peter, M. (2011). Transient activation of the HOG MAPK pathway regulates bimodal gene expression. Science, 332(6030), 732–735. https://doi.org/10.1126/science.1198851
Abstract
Abstract
Abstract
Mitogen-activated protein kinase (MAPK) cascades are conserved signalling modules that control many cellular processes by integrating intra- and extracellular cues. The p38/Hog1 MAPK is transiently activated in response to osmotic stress, leading to rapid translocation into the nucleus and induction of a specific transcriptional program. When investigating the dynamic interplay between Hog1 activation and Hog1-driven gene expression, we found that Hog1 activation increases linearly with stimulus, whereas the transcriptional output is
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Creators (Authors)
- Pelet, S
- Rudolf, F
- Nadal-Ribelles, M
- de Nadal, E
- Posas, F
- Peter, M
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Citations
Pelet, S., Rudolf, F., Nadal-Ribelles, M., de Nadal, E., Posas, F., & Peter, M. (2011). Transient activation of the HOG MAPK pathway regulates bimodal gene expression. Science, 332(6030), 732–735. https://doi.org/10.1126/science.1198851
