Cell numbers in the reflected blade of CA3 and their relation to other hippocampal principal cell populations across seven species

Maliković, Jovana; Amrein, Irmgard; Vinciguerra, Lorenzo; Lalošević, Dušan; Wolfer, David P; Slomianka, Lutz

doi:10.3389/fnana.2022.1070035

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Maliković, J., Amrein, I., Vinciguerra, L., Lalošević, D., Wolfer, D. P., & Slomianka, L. (2022). Cell numbers in the reflected blade of CA3 and their relation to other hippocampal principal cell populations across seven species. Frontiers in Neuroanatomy, 16, 1070035. https://doi.org/10.3389/fnana.2022.1070035

Abstract

The hippocampus of many mammals contains a histoarchitectural region that is not present in laboratory mice and rats-the reflected blade of the CA3 pyramidal cell layer. Pyramidal cells of the reflected blade do not extend dendrites into the hippocampal molecular layer, and recent evidence indicates that they, like the proximal CA3 pyramids in laboratory rats and mice, partially integrate functionally with the dentate circuitry in pattern separation. Quantitative assessments of phylogenetic or disease-related changes in the hippocampa