Publication: Isolation and structure determination of two microcystins and sequence comparison of the McyABC aenylation domains in Planktothrix species
Isolation and structure determination of two microcystins and sequence comparison of the McyABC aenylation domains in Planktothrix species
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Christiansen, G., Yoshida, W. Y., Blom, J. F., Portmann, C., Gademann, K., Hemscheidt, T., & Kurmayer, R. (2008). Isolation and structure determination of two microcystins and sequence comparison of the McyABC aenylation domains in Planktothrix species. Journal of Natural Products, 71, 1881–1886. https://doi.org/10.1021/np800397u
Abstract
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Abstract
Microcystins (MCs) are toxic heptapeptides found in cyanobacteria and share the common structure cyclo(-D-Ala1-L-X2-D-isoMeAsp3-L-Z4-Adda5-D-isoGlu6-Mdha7). The letters X and Z in the general formula above represent a wide range of L-amino acids that occupy positions 2 and 4, respectively. In general the variation in structural variants is due to the exchange of amino acids in position 7, 2, and 4. In the present work we report two homotyrosine (Hty)-containing microcystin variants, [D-Asp3,(E)-Dhb7]-MC-HtyY (1) and [D-Asp3,(E)-Dhb7]-
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- Christiansen, G
- Yoshida, W Y
- Blom, J F
- Portmann, C
- Gademann, K
- Hemscheidt, T
- Kurmayer, R
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Christiansen, G., Yoshida, W. Y., Blom, J. F., Portmann, C., Gademann, K., Hemscheidt, T., & Kurmayer, R. (2008). Isolation and structure determination of two microcystins and sequence comparison of the McyABC aenylation domains in Planktothrix species. Journal of Natural Products, 71, 1881–1886. https://doi.org/10.1021/np800397u
