Publication: Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells
Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells
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Guidotti, N., Eördögh, Á., Mivelaz, M., Rivera-Fuentes, P., & Fierz, B. (2023). Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells. ACS Chemical Biology, 18(5), 1066–1075. https://doi.org/10.1021/acschembio.2c00203
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Chromatin is spatially organized into functional states that are defined by both the presence of specific histone post-translational modifications (PTMs) and a defined set of chromatin-associated “reader” proteins. Different models for the underlying mechanism of such compartmentalization have been proposed, including liquid–liquid phase separation (LLPS) of chromatin-associated proteins to drive spatial organization. Heterochromatin, characterized by lysine 9 methylation on histone H3 (H3K9me3) and the presence of heterochromatin pro
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- Guidotti, Nora
- Eördögh, Ádám
- Mivelaz, Maxime
- Fierz, Beat
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H2020
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Guidotti, N., Eördögh, Á., Mivelaz, M., Rivera-Fuentes, P., & Fierz, B. (2023). Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells. ACS Chemical Biology, 18(5), 1066–1075. https://doi.org/10.1021/acschembio.2c00203
