Publication: Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics
Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics
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Obrecht, D., Robinson, J. A., Bernardini, F., Bisang, C., DeMarco, S. J., Moehle, K., & Gombert, F. O. (2009). Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics. Current Medicinal Chemistry, 16(1), 42–65. https://doi.org/10.2174/092986709787002844
Abstract
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Novel therapeutic strategies are urgently needed for the treatment of serious diseases caused by viral, bacterial and parasitic infections, because currently used drugs are facing the problem of rapidly emerging resistance. There is also an urgent need for agents that act on novel pathogen-specific targets, in order to expand the repertoire of possible therapies. The high throughput screening of diverse small molecule compound libraries has provided only a limited number of new lead series, and the number of compounds acting on novel
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Creators (Authors)
- Obrecht, D
- Robinson, J A
- Bernardini, F
- Bisang, C
- DeMarco, S J
- Moehle, K
- Gombert, F O
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Citations
Obrecht, D., Robinson, J. A., Bernardini, F., Bisang, C., DeMarco, S. J., Moehle, K., & Gombert, F. O. (2009). Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics. Current Medicinal Chemistry, 16(1), 42–65. https://doi.org/10.2174/092986709787002844
