Publication: Investigation of the Therapeutic Effect of an Fc-Domain Polythiophene Conjugate in Prion Diseases
Investigation of the Therapeutic Effect of an Fc-Domain Polythiophene Conjugate in Prion Diseases
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Zhang, H. (2024). Investigation of the Therapeutic Effect of an Fc-Domain Polythiophene Conjugate in Prion Diseases. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-259375
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There is a highly unmet medical need for treatments in neurodegenerative diseases including prion diseases (PrDs), Alzheimer's (AD) and Parkinson's disease (PD). Pathologically, misfolded protein aggregates are hallmarks of these protein misfolding diseases, e.g., prions in PrDs, amyloid-β (Aβ) and tau aggregates in AD, α-synuclein (α-syn) and tau aggregates in PD. In recent years, two monoclonal antibodies that target Aβ aggregates have been approved to treat AD by opsonizing Aβ aggregates and enhancing microglial phagocytosis but sh
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Zhang, H. (2024). Investigation of the Therapeutic Effect of an Fc-Domain Polythiophene Conjugate in Prion Diseases. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-259375
