Publication: Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks
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Myren‐Svelstad, S., Jamali, A., Ophus, S. S., D’gama, P. P., Ostenrath, A. M., Mutlu, A. K., Hoffshagen, H. H., Hotz, A. L., Neuhauss, S. C. F., Jurisch‐Yaksi, N., & Yaksi, E. (2022). Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia, 63(10), 2543–2560. https://doi.org/10.1111/epi.17380
Abstract
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Objective: The switch between nonseizure and seizure states involves profound alterations in network excitability and synchrony. In this study, we aimed to identify and compare features of neural excitability and dynamics across multiple zebrafish seizure and epilepsy models.
Methods: Inspired by video-electroencephalographic recordings in patients, we developed a framework to study spontaneous and photically evoked neural and locomotor activity in zebrafish larvae, by combining high-throughput behavioral tracking and whole-brain in
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- Myren‐Svelstad, Sverre
- Jamali, Ahmed
- Ophus, Sunniva S
- D'gama, Percival P
- Ostenrath, Anna M
- Mutlu, Aytac Kadir
- Hoffshagen, Helene Homme
- Hotz, Adriana L
- Jurisch‐Yaksi, Nathalie
- Yaksi, Emre
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Myren‐Svelstad, S., Jamali, A., Ophus, S. S., D’gama, P. P., Ostenrath, A. M., Mutlu, A. K., Hoffshagen, H. H., Hotz, A. L., Neuhauss, S. C. F., Jurisch‐Yaksi, N., & Yaksi, E. (2022). Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia, 63(10), 2543–2560. https://doi.org/10.1111/epi.17380
