Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder

Segura, Mònica; Pedreño, Carla; Obiols, Jordi; Taurines, Regina; Pàmias, Montserrat; Grünblatt, Edna; Gella, Alejandro

doi:10.1007/s10048-014-0434-9

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Segura, M., Pedreño, C., Obiols, J., Taurines, R., Pàmias, M., Grünblatt, E., & Gella, A. (2015). Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder. Neurogenetics, 16(2), 123–131. https://doi.org/10.1007/s10048-014-0434-9

Abstract

Autism spectrum disorders (ASD) comprise neurodevelopmental disorders with clinical onset during the first years of life. The identification of peripheral biomarkers could significantly impact diagnosis and an individualized, early treatment. Although the aetiology of ASD remains poorly understood, there is increasing evidence that neurotrophins and their receptors represent a group of candidate genes for ASD pathophysiology and biomarker research. Total messenger RNA (mRNA) from whole blood was obtained from adolescents and adults di