Publication: Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors
Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors
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Saydam, N., Kanagaraj, R., Dietschy, T., Garcia, P. L., Peña-Diaz, J., Shevelev, I., Stagljar, I., & Janscak, P. (2007). Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Research, 35, 5706–5716. https://doi.org/10.1093/nar/gkm500
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Werner syndrome (WS) is a severe recessive disorder characterized by premature aging, cancer predisposition and genomic instability. The gene mutated in WS encodes a bi-functional enzyme called WRN that acts as a RecQ-type DNA helicase and a 3'-5' exonuclease, but its exact role in DNA metabolism is poorly understood. Here we show that WRN physically interacts with the MSH2/MSH6 (MutSalpha), MSH2/MSH3 (MutSbeta) and MLH1/PMS2 (MutLalpha) heterodimers that are involved in the initiation of mismatch repair (MMR) and the rejection of hom
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- Saydam, N
- Kanagaraj, R
- Dietschy, T
- Peña-Diaz, J
- Shevelev, I
- Stagljar, I
- Janscak, Pavel
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Saydam, N., Kanagaraj, R., Dietschy, T., Garcia, P. L., Peña-Diaz, J., Shevelev, I., Stagljar, I., & Janscak, P. (2007). Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Research, 35, 5706–5716. https://doi.org/10.1093/nar/gkm500
