A three-dimensional quantification of calcified and non-calcified plaques in coronary arteries based on computed tomography coronary angiography images: Comparison with expert's annotations and virtual histology intravascular ultrasound

Kigka, Vassiliki I; Sakellarios, Antonis; Kyriakidis, Savvas; Rigas, George; Athanasiou, Lambros; Siogkas, Panagiotis; Tsompou, Panagiota; Loggitsi, Dimitra; Benz, Dominik C; Buechel, Ronny; Lemos, Pedro A; Pelosi, Gualtiero; Michalis, Lampros K; Fotiadis, Dimitrios I

doi:10.1016/j.compbiomed.2019.103409

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Kigka, V. I., Sakellarios, A., Kyriakidis, S., Rigas, G., Athanasiou, L., Siogkas, P., Tsompou, P., Loggitsi, D., Benz, D. C., Buechel, R., Lemos, P. A., Pelosi, G., Michalis, L. K., & Fotiadis, D. I. (2019). A three-dimensional quantification of calcified and non-calcified plaques in coronary arteries based on computed tomography coronary angiography images: Comparison with expert’s annotations and virtual histology intravascular ultrasound. Computers in Biology and Medicine, 113, 103409. https://doi.org/10.1016/j.compbiomed.2019.103409

Abstract

The detection, quantification and characterization of coronary atherosclerotic plaques has a major effect on the diagnosis and treatment of coronary artery disease (CAD). Different studies have reported and evaluated the noninvasive ability of Computed Tomography Coronary Angiography (CTCA) to identify coronary plaque features. The identification of calcified plaques (CP) and non-calcified plaques (NCP) using CTCA has been extensively studied in cardiovascular research. However, NCP detection remains a challenging problem in CTCA imag