Microporosities in 3D-Printed Tricalcium-Phosphate-Based Bone Substitutes Enhance Osteoconduction and Affect Osteoclastic Resorption

Ghayor, Chafik; Chen, Tse-Hsiang; Bhattacharya, Indranil; Özcan, Mutlu; Weber, Franz E

doi:10.3390/ijms21239270

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Ghayor, C., Chen, T.-H., Bhattacharya, I., Özcan, M., & Weber, F. E. (2020). Microporosities in 3D-Printed Tricalcium-Phosphate-Based Bone Substitutes Enhance Osteoconduction and Affect Osteoclastic Resorption. International Journal of Molecular Sciences, 21(23), 9270. https://doi.org/10.3390/ijms21239270

Abstract

Additive manufacturing is a key technology required to realize the production of a personalized bone substitute that exactly meets a patient's need and fills a patient-specific bone defect. Additive manufacturing can optimize the inner architecture of the scaffold for osteoconduction, allowing fast and reliable defect bridging by promoting rapid growth of new bone tissue into the scaffold. The role of scaffold microporosity/nanoarchitecture in osteoconduction remains elusive. To elucidate this relationship, we produced lithography-bas