Publication: Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19
Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19
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Sinnberg, T., Lichtensteiger, C., Hasan Ali, O., et al, Brugger, S. D., Mairpady Shambat, S., Buehler, P. K., & Scheier, T. C. (2023). Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19. American Journal of Respiratory and Critical Care Medicine, 207(1), 38–49. https://doi.org/10.1164/rccm.202201-0011oc
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Rationale: Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome with fatal outcomes. Evidence suggests that dysregulated immune responses, including autoimmunity, are key pathogenic factors.
Objectives: To assess whether IgA autoantibodies target lung-specific proteins and contribute to disease severity.
Methods: We collected 147 blood, 9 lung tissue, and 36 bronchoalveolar lavage fluid samples from three tertiary hospitals in Switzerland and one in Germany. Severe COVID-19 was defined by the need to a
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Sinnberg, T., Lichtensteiger, C., Hasan Ali, O., et al, Brugger, S. D., Mairpady Shambat, S., Buehler, P. K., & Scheier, T. C. (2023). Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19. American Journal of Respiratory and Critical Care Medicine, 207(1), 38–49. https://doi.org/10.1164/rccm.202201-0011oc
