Publication: Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output
Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output
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Hodge, R. D., Kowalczyk, T. D., Wolf, S. A., Encinas, J. M., Rippey, C., Enikolopov, G., Kempermann, G., & Hevner, R. F. (2008). Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output. Journal of Neuroscience, 28(14), 3707–3717. https://doi.org/10.1523/JNEUROSCI.4280-07.2008
Abstract
Abstract
Abstract
Neurogenesis in the adult hippocampus is a highly regulated process that originates from multipotent progenitors in the subgranular zone (SGZ). Currently, little is known about molecular mechanisms that regulate proliferation and differentiation in the SGZ. To study the role of transcription factors (TFs), we focused on Tbr2 (T-box brain gene 2), which has been implicated previously in developmental glutamatergic neurogenesis. In adult mouse hippocampus, Tbr2 protein and Tbr2-GFP (green fluorescent protein) transgene expression were s
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- Hodge, R D
- Kowalczyk, T D
- Wolf, S A
- Encinas, J M
- Rippey, C
- Enikolopov, G
- Kempermann, G
- Hevner, R F
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Hodge, R. D., Kowalczyk, T. D., Wolf, S. A., Encinas, J. M., Rippey, C., Enikolopov, G., Kempermann, G., & Hevner, R. F. (2008). Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output. Journal of Neuroscience, 28(14), 3707–3717. https://doi.org/10.1523/JNEUROSCI.4280-07.2008
