Publication: Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model
Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model
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Occhetta, P., Mainardi, A., Votta, E., Vallmajo-Martin, Q., Ehrbar, M., Martin, I., Barbero, A., & Rasponi, M. (2019). Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model. Nature Biomedical Engineering, 3(7), 545–557. https://doi.org/10.1038/s41551-019-0406-3
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Owing to population aging, the social impact of osteoarthritis (OA)-the most common musculoskeletal disease-is expected to increase dramatically. Yet, therapy is still limited to palliative treatments or surgical intervention, and disease-modifying OA (DMOA) drugs are scarce, mainly because of the absence of relevant preclinical OA models. Therefore, in vitro models that can reliably predict the efficacy of DMOA drugs are needed. Here, we show, using a newly developed microphysiological cartilage-on-a-chip model that enables the appli
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- Occhetta, Paola
- Mainardi, Andrea
- Votta, Emiliano
- Vallmajo-Martin, Queralt
- Martin, Ivan
- Barbero, Andrea
- Rasponi, Marco
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Occhetta, P., Mainardi, A., Votta, E., Vallmajo-Martin, Q., Ehrbar, M., Martin, I., Barbero, A., & Rasponi, M. (2019). Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model. Nature Biomedical Engineering, 3(7), 545–557. https://doi.org/10.1038/s41551-019-0406-3
