Publication: DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development
DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development
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Binder, H., Willscher, E., Loeffler-Wirth, H., Hopp, L., Jones, D. T. W., Pfister, S. M., Kreuz, M., et al, & Weller, M. (2019). DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development. Acta Neuropathologica Communications, 7(1), 59. https://doi.org/10.1186/s40478-019-0704-8
Abstract
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BACKGROUND Diffuse lower WHO grade II and III gliomas (LGG) are slowly progressing brain tumors, many of which eventually transform into a more aggressive type. LGG is characterized by widespread genetic and transcriptional heterogeneity, yet little is known about the heterogeneity of the DNA methylome, its function in tumor biology, coupling with the transcriptome and tumor microenvironment and its possible impact for tumor development. METHODS We here present novel DNA methylation data of an LGG-cohort collected in the German Glioma
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- Binder, H
- Willscher, E
- Loeffler-Wirth, H
- Hopp, L
- Jones, D T W
- Pfister, S M
- Kreuz, M
- Weller, Michael
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Citations
Binder, H., Willscher, E., Loeffler-Wirth, H., Hopp, L., Jones, D. T. W., Pfister, S. M., Kreuz, M., et al, & Weller, M. (2019). DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development. Acta Neuropathologica Communications, 7(1), 59. https://doi.org/10.1186/s40478-019-0704-8
