Publication: Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage
Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage
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Kanagaraj, R., Parasuraman, P., Mihaljevic, B., van Loon, B., Burdova, K., König, C., Furrer, A., Bohr, V. A., Hübscher, U., & Janscak, P. (2012). Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage. Nucleic Acids Research, 40, 8449–8459. https://doi.org/10.1093/nar/gks648
Abstract
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Abstract
Reactive oxygen species constantly generated as by-products of cellular metabolism readily attack genomic DNA creating mutagenic lesions such as 7,8-dihydro-8-oxo-guanine (8-oxo-G) that promote aging. 8-oxo-G:A mispairs arising during DNA replication are eliminated by base excision repair initiated by the MutY DNA glycosylase homologue (MUTYH). Here, by using formaldehyde crosslinking in mammalian cell extracts, we demonstrate that the WRN helicase/exonuclease defective in the premature aging disorder Werner syndrome (WS) is recruited
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Creators (Authors)
- Kanagaraj, Radhakrishnan
- Parasuraman, Prasanna
- Mihaljevic, Boris
- van Loon, Barbara
- Burdova, Kamila
- König, Christiane
- Furrer, Antonia
- Bohr, Vilhelm A
- Hübscher, Ulrich
- Janscak, Pavel
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Citations
Kanagaraj, R., Parasuraman, P., Mihaljevic, B., van Loon, B., Burdova, K., König, C., Furrer, A., Bohr, V. A., Hübscher, U., & Janscak, P. (2012). Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage. Nucleic Acids Research, 40, 8449–8459. https://doi.org/10.1093/nar/gks648
