Publication: Immune monitoring-guided vs fixed duration of antiviral prophylaxis against cytomegalovirus in solid-organ transplant recipients. A Multicenter, Randomized Clinical Trial
Immune monitoring-guided vs fixed duration of antiviral prophylaxis against cytomegalovirus in solid-organ transplant recipients. A Multicenter, Randomized Clinical Trial
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Manuel, O., Laager, M., Hirzel, C., Neofytos, D., Walti, L. N., Hoenger, G., Binet, I., Schnyder, A., Stampf, S., Koller, M., Mombelli, M., Kim, M. J., Hoffmann, M., Koenig, K., Hess, C., Burgener, A.-V., Cippà, P. E., Hübel, K., Mueller, T. F., … Mueller, N. J. (2024). Immune monitoring-guided vs fixed duration of antiviral prophylaxis against cytomegalovirus in solid-organ transplant recipients. A Multicenter, Randomized Clinical Trial. Clinical Infectious Diseases, 78(2), 312–323. https://doi.org/10.1093/cid/ciad575
Abstract
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BACKGROUND: The use of assays detecting cytomegalovirus (CMV)-specific T-cell-mediated immunity may individualize the duration of antiviral prophylaxis in transplant recipients.
METHODS: In this open-label randomized trial, adult kidney and liver transplant recipients from six centers in Switzerland were enrolled if they were CMV-seronegative with seropositive donors or CMV-seropositive receiving anti-thymocyte globulins. Patients were randomized to a duration of antiviral prophylaxis based on immune-monitoring (intervention) or a fi
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Manuel, O., Laager, M., Hirzel, C., Neofytos, D., Walti, L. N., Hoenger, G., Binet, I., Schnyder, A., Stampf, S., Koller, M., Mombelli, M., Kim, M. J., Hoffmann, M., Koenig, K., Hess, C., Burgener, A.-V., Cippà, P. E., Hübel, K., Mueller, T. F., … Mueller, N. J. (2024). Immune monitoring-guided vs fixed duration of antiviral prophylaxis against cytomegalovirus in solid-organ transplant recipients. A Multicenter, Randomized Clinical Trial. Clinical Infectious Diseases, 78(2), 312–323. https://doi.org/10.1093/cid/ciad575
