Publication: The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes
The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes
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Schaffner, C. A., Mwinyi, J., Gai, Z., Thasler, W. E., Eloranta, J. J., & Kullak-Ublick, G. A. (2015). The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes. Liver International, 35, 1152–1161. https://doi.org/10.1111/liv.12558
Abstract
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Abstract
BACKGROUND & AIMS The organic solute transporters alpha and beta (OSTα-OSTβ) form a heterodimeric transporter located at the basolateral membrane of intestinal epithelial cells and hepatocytes. Liver injury caused by ischaemia-reperfusion, cancer, inflammation or cholestasis can induce a state of hypoxia in hepatocytes. Here, we studied the effect of hypoxia on the expression of OSTα-OSTβ. METHODS OSTα-OSTβ expression was measured in Huh7 cells and primary human hepatocytes (PHH) exposed to chenodeoxycholic acid (CDCA), hypoxia or bot
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Creators (Authors)
- Schaffner, Carlos A
- Mwinyi, Jessica
- Gai, Zhibo
- Thasler, Wolfgang E
- Eloranta, Jyrki J
- Kullak-Ublick, Gerd A
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Citations
Schaffner, C. A., Mwinyi, J., Gai, Z., Thasler, W. E., Eloranta, J. J., & Kullak-Ublick, G. A. (2015). The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes. Liver International, 35, 1152–1161. https://doi.org/10.1111/liv.12558
