Effects on Cognitive Functioning of Acute, Subacute and Repeated Exposures to High Altitude

Pun, Matiram; Guadagni, Veronica; Bettauer, Kaitlyn M; Drogos, Lauren L; Aitken, Julie; Hartmann, Sara E; Furian, Michael; Muralt, Lara; Lichtblau, Mona; Bader, Patrick R; Rawling, Jean M; Protzner, Andrea B; Ulrich, Silvia; Bloch, Konrad E; Giesbrecht, Barry; Poulin, Marc J

doi:10.3389/fphys.2018.01131

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Pun, M., Guadagni, V., Bettauer, K. M., Drogos, L. L., Aitken, J., Hartmann, S. E., Furian, M., Muralt, L., Lichtblau, M., Bader, P. R., Rawling, J. M., Protzner, A. B., Ulrich, S., Bloch, K. E., Giesbrecht, B., & Poulin, M. J. (2018). Effects on Cognitive Functioning of Acute, Subacute and Repeated Exposures to High Altitude. Frontiers in Physiology, 9, 1131. https://doi.org/10.3389/fphys.2018.01131

Abstract

Neurocognitive functions are affected by high altitude, however the altitude effects of acclimatization and repeated exposures are unclear. We investigated the effects of acute, subacute and repeated exposure to 5,050 m on cognition among altitude-naïve participants compared to control subjects tested at low altitude. Twenty-one altitude-naïve individuals (25.3 ± 3.8 years, 13 females) were exposed to 5,050 m for 1 week ( and re-exposed after a week of rest at sea-level (). Baseline (BL, 520 m), acute (Day 1, HA1) and acclimatization