Publication: Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens
Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens
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Vollenweider, V., Rehm, K., Chepkirui, C., Pérez-Berlanga, M., Polymenidou, M., Piel, J., Bigler, L., & Kümmerli, R. (2024). Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens. ELife, 13, RP92493. https://doi.org/10.7554/eLife.92493.3
Abstract
Abstract
Abstract
The global rise of antibiotic resistance calls for new drugs against bacterial pathogens. A common approach is to search for natural compounds deployed by microbes to inhibit competitors. Here, we show that the iron-chelating pyoverdines, siderophores produced by environmental Pseudomonas spp., have strong antibacterial properties by inducing iron starvation and growth arrest in pathogens. A screen of 320 natural Pseudomonas isolates used against 12 human pathogens uncovered several pyoverdines with particularly high antibacterial pro
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Creators (Authors)
- Vollenweider, Vera
- Rehm, Karoline
- Chepkirui, Clara
- Pérez-Berlanga, Manuela
- Polymenidou, Magdalini
- Piel, Jörn
- Kümmerli, Rolf
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Citations
Vollenweider, V., Rehm, K., Chepkirui, C., Pérez-Berlanga, M., Polymenidou, M., Piel, J., Bigler, L., & Kümmerli, R. (2024). Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens. ELife, 13, RP92493. https://doi.org/10.7554/eLife.92493.3
