Publication: Common ABCB4 and ABCB11 Genotypes Are Associated with Idiopathic Chronic Cholestasis in Adults
Common ABCB4 and ABCB11 Genotypes Are Associated with Idiopathic Chronic Cholestasis in Adults
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Jüngst, C., Justinger, C., Fischer, J., Berg, T., & Lammert, F. (2022). Common ABCB4 and ABCB11 Genotypes Are Associated with Idiopathic Chronic Cholestasis in Adults. Digestive Diseases, 40(4), 489–496. https://doi.org/10.1159/000518203
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INTRODUCTION: Pathogenic mutations in genes encoding the hepatocanalicular transporters ATP8B1, ABCB11 and ABCB4 are causative for progressive cholestatic liver disease in children. In adults, less severe variants such as the common ABCB4 c.711A>T polymorphism have been associated with intrahepatic cholestasis in pregnancy and elevated liver enzymes. Hence, our aim was to study the role of common polymorphisms in adult patients with chronic unexplained cholestasis.
METHODS: Screening of outpatients of two university hospitals identif
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- Jüngst, Christoph
- Justinger, Christina
- Fischer, Janett
- Berg, Thomas
- Lammert, Frank
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Jüngst, C., Justinger, C., Fischer, J., Berg, T., & Lammert, F. (2022). Common ABCB4 and ABCB11 Genotypes Are Associated with Idiopathic Chronic Cholestasis in Adults. Digestive Diseases, 40(4), 489–496. https://doi.org/10.1159/000518203
