Publication: Decoupling HIV-1 antiretroviral drug inhibition from plasma antibody activity to evaluate broadly neutralizing antibody therapeutics and vaccines
Decoupling HIV-1 antiretroviral drug inhibition from plasma antibody activity to evaluate broadly neutralizing antibody therapeutics and vaccines
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Schwarzmüller, M., Lozano, C., Schanz, M., Abela, I. A., Grosse-Holz, S., Epp, S., Curcio, M., Greshake, J., Rusert, P., Huber, M., Kouyos, R. D., Günthard, H. F., Trkola, A., & Swiss HIV Cohort Study. (2024). Decoupling HIV-1 antiretroviral drug inhibition from plasma antibody activity to evaluate broadly neutralizing antibody therapeutics and vaccines. Cell Reports Medicine, 5(9), 101702. https://doi.org/10.1016/j.xcrm.2024.101702
Abstract
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The development of broadly neutralizing antibody (bnAb)-based therapeutic HIV-1 vaccines and cure concepts depends on monitoring bnAb plasma activity in people with HIV (PWH) on suppressive antiretroviral therapy (ART). To enable this, analytical strategies must be defined to reliably distinguish antibody-based neutralization from drug inhibition. Here, we explore strategies that either utilize drug-resistant viruses or remove drugs from plasma. We develop ART-DEX (ART dissociation and size exclusion), an approach which quantitatively
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- Schwarzmüller, Magdalena
- Lozano, Cristina
- Schanz, Merle
- Abela, Irene A
- Grosse-Holz, Silvan
- Epp, Selina
- Curcio, Martina
- Greshake, Jule
- Rusert, Peter
- Kouyos, Roger D
- Günthard, Huldrych F
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Schwarzmüller, M., Lozano, C., Schanz, M., Abela, I. A., Grosse-Holz, S., Epp, S., Curcio, M., Greshake, J., Rusert, P., Huber, M., Kouyos, R. D., Günthard, H. F., Trkola, A., & Swiss HIV Cohort Study. (2024). Decoupling HIV-1 antiretroviral drug inhibition from plasma antibody activity to evaluate broadly neutralizing antibody therapeutics and vaccines. Cell Reports Medicine, 5(9), 101702. https://doi.org/10.1016/j.xcrm.2024.101702
