Publication: Proteomic identification of proliferation and progression markers in human polycythemia vera stem and progenitor cells
Proteomic identification of proliferation and progression markers in human polycythemia vera stem and progenitor cells
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Tan, G., Wolski, W. E., Kummer, S., Hofstetter, M. C., Theocharides, A. P. A., Manz, M. G., Aebersold, R., & Meier-Abt, F. (2022). Proteomic identification of proliferation and progression markers in human polycythemia vera stem and progenitor cells. Blood Advances, 6, 3480–3493. https://doi.org/10.1182/bloodadvances.2021005344
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Polycythemia vera (PV) is a stem cell disorder characterized by hyperproliferation of the myeloid lineages and the presence of an activating JAK2 mutation. To elucidate mechanisms controlling PV stem and progenitor cell biology, we applied a recently developed highly sensitive data-independent acquisition mass spectrometry workflow to purified hematopoietic stem and progenitor cell (HSPC) subpopulations of patients with chronic and progressed PV. We integrated proteomic data with genomic, transcriptomic, flow cytometry and in vitro co
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Tan, G., Wolski, W. E., Kummer, S., Hofstetter, M. C., Theocharides, A. P. A., Manz, M. G., Aebersold, R., & Meier-Abt, F. (2022). Proteomic identification of proliferation and progression markers in human polycythemia vera stem and progenitor cells. Blood Advances, 6, 3480–3493. https://doi.org/10.1182/bloodadvances.2021005344
