Publication: Chemistry and Biology of the Clinically Used Macrolactone Antibiotic Fidaxomicin
Chemistry and Biology of the Clinically Used Macrolactone Antibiotic Fidaxomicin
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Dorst, A., & Gademann, K. (2020). Chemistry and Biology of the Clinically Used Macrolactone Antibiotic Fidaxomicin. Helvetica Chimica Acta, 103(4), e2000038. https://doi.org/10.1002/hlca.202000038
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Fidaxomicin (1, lipiarmycin A3, clostomicin B1, tiacumicin B) constitutes a glycosylated 18-membered macrolactone and is a natural product isolated from various soil bacteria. Since 2011, fidaxomicin is a marketed antibiotic for the treatment of intestine infections caused by C. difficile in the clinic. Its promising in vitro antibacterial properties against resistant S. aureus and M. tuberculosis continue to attract interest. This review article describes the early history of the antibiotic fidaxomicin and highlights recent advances
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- Dorst, Andrea
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Dorst, A., & Gademann, K. (2020). Chemistry and Biology of the Clinically Used Macrolactone Antibiotic Fidaxomicin. Helvetica Chimica Acta, 103(4), e2000038. https://doi.org/10.1002/hlca.202000038
