Publication: Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder
Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder
Date
Date
Date
Citations
Akkus, F., Mihov, Y., Treyer, V., Ametamey, S. M., Johayem, A., Senn, S., Rösner, S., Buck, A., & Hasler, G. (2018). Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder. Translational Psychiatry, 8, 17. https://doi.org/10.1038/s41398-017-0066-6
Abstract
Abstract
Abstract
Glutamate signaling plays a major role in addiction. Preclinical research strongly suggests an implication of G-protein-coupled metabotropic glutamate receptor subtype 5 (mGluR5) in nicotine addiction and alcohol use disorder. In humans, smoking is related to a global reduction in mGluR5 availability. In the present study, we investigated mGluR5 in vivo in patients with alcohol use disorder without the confounding effects of smoking. A total of 14 male subjects with alcohol use disorder and at least a 25-day abstinence and 14 matched
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Creators (Authors)
- Akkus, Funda
- Mihov, Yoan
- Ametamey, Simon M
- Johayem, Anass
- Senn, Smeralda
- Rösner, Susanne
- Buck, Alfred
- Hasler, Gregor
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Citations
Akkus, F., Mihov, Y., Treyer, V., Ametamey, S. M., Johayem, A., Senn, S., Rösner, S., Buck, A., & Hasler, G. (2018). Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder. Translational Psychiatry, 8, 17. https://doi.org/10.1038/s41398-017-0066-6
