Publication: α-synuclein insertion into supported lipid bilayers as seen by in situ x-ray reflectivity
α-synuclein insertion into supported lipid bilayers as seen by in situ x-ray reflectivity
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Hähl, H., Möller, I., Kiesel, I., Campioni, S., Riek, R., Verdes, D., & Seeger, S. (2015). α-synuclein insertion into supported lipid bilayers as seen by in situ x-ray reflectivity. ACS Chemical Neuroscience, 6(3), 374–379. https://doi.org/10.1021/cn5002683
Abstract
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Abstract
Large aggregates of misfolded α-synuclein inside neuronal cells are the hallmarks of Parkinson’s disease. The protein’s natural function and its supposed toxicity, however, are believed to be closely related to its interaction with cell and vesicle membranes. Upon this interaction, the protein folds into an α-helical structure and intercalates into the membrane. In this study, we focus on the changes in the lipid bilayer caused by this intrusion. In situ X-ray reflectivity was applied to determine the vertical density structure of the
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- Hähl, Hendrik
- Möller, Isabelle
- Kiesel, Irena
- Campioni, Silvia
- Riek, Roland
- Verdes, Dorinel
- Seeger, Stefan
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Hähl, H., Möller, I., Kiesel, I., Campioni, S., Riek, R., Verdes, D., & Seeger, S. (2015). α-synuclein insertion into supported lipid bilayers as seen by in situ x-ray reflectivity. ACS Chemical Neuroscience, 6(3), 374–379. https://doi.org/10.1021/cn5002683
