Publication: A chronic hypoxic response in photoreceptors alters the vitreous proteome in mice
A chronic hypoxic response in photoreceptors alters the vitreous proteome in mice
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Schori, C., Trachsel, C., Grossmann, J., Barben, M., Klee, K., Storti, F., Samardzija, M., & Grimm, C. (2019). A chronic hypoxic response in photoreceptors alters the vitreous proteome in mice. Experimental Eye Research, 185, 107690. https://doi.org/10.1016/j.exer.2019.107690
Abstract
Abstract
Abstract
Reduced oxygenation of the outer retina in the aging eye may activate a chronic hypoxic response in RPE and photoreceptor cells and is considered as a risk factor for the development of age-related macular degeneration (AMD). In mice, a chronically active hypoxic response in the retinal pigment epithelium (RPE) or photoreceptors leads to age-dependent retinal degeneration. To identify proteins that may serve as accessible markers for a chronic hypoxic insult to photoreceptors, we used proteomics to determine the protein composition of
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Creators (Authors)
- Schori, Christian
- Trachsel, Christian
- Grossmann, Jonas
- Barben, Maya
- Klee, Katrin
- Storti, Federica
- Samardzija, Marijana
- Grimm, Christian
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Citations
Schori, C., Trachsel, C., Grossmann, J., Barben, M., Klee, K., Storti, F., Samardzija, M., & Grimm, C. (2019). A chronic hypoxic response in photoreceptors alters the vitreous proteome in mice. Experimental Eye Research, 185, 107690. https://doi.org/10.1016/j.exer.2019.107690
