Publication: The inflammasomes in autoinflammatory diseases with skin involvement
The inflammasomes in autoinflammatory diseases with skin involvement
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Beer, H.-D., Contassot, E., & French, L. E. (2014). The inflammasomes in autoinflammatory diseases with skin involvement. Journal of Investigative Dermatology, 134(7), 1805–1810. https://doi.org/10.1038/jid.2014.76
Abstract
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Abstract
During the past years, significant progress in the understanding of the complexity, regulation, and relevance of innate immune responses underlying several inflammatory conditions with neutrophilic skin involvement has been made. These diseases belong to the novel class of autoinflammatory diseases, and several are caused by mutations in genes regulating the function of innate immune complexes, termed inflammasomes, leading to enhanced secretion of the proinflammatory cytokine IL-1β. Consequently, targeting of IL-1β has proven success
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Creators (Authors)
- Beer, Hans-Dietmar
- Contassot, Emmanuel
- French, Lars E
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Citations
Beer, H.-D., Contassot, E., & French, L. E. (2014). The inflammasomes in autoinflammatory diseases with skin involvement. Journal of Investigative Dermatology, 134(7), 1805–1810. https://doi.org/10.1038/jid.2014.76