Publication: Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype
Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype
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Tudeau, L., Acuña, M. A., Albisetti, G. W., Neumann, E., Ralvenius, W. T., Scheurer, L., Poe, M., Cook, J. M., Johannssen, H. C., & Zeilhofer, H. U. (2020). Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype. Brain Research, 1741, 146889. https://doi.org/10.1016/j.brainres.2020.146889
Abstract
Abstract
Abstract
Diminished synaptic inhibition in the superficial spinal dorsal horn contributes to exaggerated pain responses that accompany peripheral inflammation and neuropathy. α2GABAA receptors (α2GABAAR) constitute the most abundant GABAAR subtype at this site and are the targets of recently identified antihyperalgesic compounds. Surprisingly, hoxb8-α2−/− mice that lack α2GABAAR from the spinal cord and peripheral sensory neurons exhibit unaltered sensitivity to acute painful stimuli and develop normal inflammatory and neuropathic hyperalgesia
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- Tudeau, Laetitia
- Acuña, Mario A
- Albisetti, Gioele W
- Neumann, Elena
- Ralvenius, William T
- Scheurer, Louis
- Poe, Michael
- Cook, James M
- Johannssen, Helge C
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Tudeau, L., Acuña, M. A., Albisetti, G. W., Neumann, E., Ralvenius, W. T., Scheurer, L., Poe, M., Cook, J. M., Johannssen, H. C., & Zeilhofer, H. U. (2020). Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype. Brain Research, 1741, 146889. https://doi.org/10.1016/j.brainres.2020.146889
