Publication: Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer.
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer.
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O’Rourke, K. P., Loizou, E., Livshits, G., Schatoff, E. M., Baslan, T., Manchado, E., Simon, J., Romesser, P. B., Leach, B., Han, T., Pauli, C., Beltran, H., Rubin, M. A., Dow, L. E., & Lowe, S. W. (2017). Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. Nature Biotechnology, 35(6), 1–8. https://doi.org/10.1038/nbt.3837
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Colorectal cancer (CRC) is a leading cause of death in the developed world, yet facile preclinical models that mimic the natural stages of CRC progression are lacking. Through the orthotopic engraftment of colon organoids we describe a broadly usable immunocompetent CRC model that recapitulates the entire adenoma-adenocarcinoma-metastasis axis in vivo. The engraftment procedure takes less than 5 minutes, shows efficient tumor engraftment in two-thirds of mice, and can be achieved using organoids derived from genetically engineered mou
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Creators (Authors)
- O'Rourke, Kevin P
- Loizou, Evangelia
- Livshits, Geulah
- Schatoff, Emma M
- Baslan, Timour
- Manchado, Eusebio
- Simon, Janelle
- Romesser, Paul B
- Leach, Benjamin
- Han, Teng
- Pauli, Chantal
- Beltran, Himisha
- Rubin, Mark A
- Dow, Lukas E
- Lowe, Scott W
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O’Rourke, K. P., Loizou, E., Livshits, G., Schatoff, E. M., Baslan, T., Manchado, E., Simon, J., Romesser, P. B., Leach, B., Han, T., Pauli, C., Beltran, H., Rubin, M. A., Dow, L. E., & Lowe, S. W. (2017). Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. Nature Biotechnology, 35(6), 1–8. https://doi.org/10.1038/nbt.3837
