Publication: Engineered Platelet‐Derived Growth Factor‐Releasing Hydrogels Promote Fetal Membrane Healing In Vivo
Engineered Platelet‐Derived Growth Factor‐Releasing Hydrogels Promote Fetal Membrane Healing In Vivo
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Avilla‐Royo, E., Vonzun, L., Seehusen, F., Vallmajo‐Martin, Q., Famos, F., Moser, L., Gegenschatz‐Schmid, K., Krattiger, L. A., Strübing, N., Weisskopf, M., Moehrlen, U., Ochsenbein‐Kölble, N., & Ehrbar, M. (2023). Engineered Platelet‐Derived Growth Factor‐Releasing Hydrogels Promote Fetal Membrane Healing In Vivo. Advanced Functional Materials, 33, 2208910. https://doi.org/10.1002/adfm.202208910
Abstract
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Abstract
Fetoscopic interventions to treat fetal anomalies are currently performed for a variety of conditions. Depending on the procedure, preterm rupture of the fetal membranes (FMs) happens in around 30% of the cases, potentially leading to preterm birth and fetal morbidity and mortality. Here, the capacity of modular transglutaminase crosslinked poly(ethylene glycol) (TG‐PEG) hydrogels that release platelet‐derived growth factor (PDGF)‐BB to promote FM healing is described. In vitro, such growth factor‐loaded hydrogels are able to stimulat
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Creators (Authors)
- Avilla‐Royo, Eva
- Vonzun, Ladina
- Seehusen, Frauke
- Vallmajo‐Martin, Queralt
- Famos, Flurina
- Moser, Lukas
- Gegenschatz‐Schmid, Katharina
- Krattiger, Lisa Amanda
- Strübing, Nele
- Weisskopf, Miriam
- Moehrlen, Ueli
- Ochsenbein‐Kölble, Nicole
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Avilla‐Royo, E., Vonzun, L., Seehusen, F., Vallmajo‐Martin, Q., Famos, F., Moser, L., Gegenschatz‐Schmid, K., Krattiger, L. A., Strübing, N., Weisskopf, M., Moehrlen, U., Ochsenbein‐Kölble, N., & Ehrbar, M. (2023). Engineered Platelet‐Derived Growth Factor‐Releasing Hydrogels Promote Fetal Membrane Healing In Vivo. Advanced Functional Materials, 33, 2208910. https://doi.org/10.1002/adfm.202208910
