Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis

Razzaghi Khamesi, Pooya; Charitatos, Vasileios; Heerfordt, Eva K; MacAulay, Nanna; Kurtcuoglu, Vartan

doi:10.1186/s12987-023-00419-2

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Razzaghi Khamesi, P., Charitatos, V., Heerfordt, E. K., MacAulay, N., & Kurtcuoglu, V. (2023). Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis. Fluids and Barriers of the CNS, 20(1), 18. https://doi.org/10.1186/s12987-023-00419-2

Abstract

Background: The mechanisms of cerebrospinal fluid (CSF) production by the ventricular choroid plexus (ChP) have not been fully deciphered. One prominent hypothesized mechanism is trans-epithelial water transport mediated by accumulation of solutes at the luminal ChP membrane that produces local osmotic gradients. However, this standing osmotic gradient hypothesis has not been systematically tested. Methods: To assess the plausibility of the standing gradient mechanism serving as the main driver of CSF production by the ChP, we develop