Publication: RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis
RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis
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Di Marco, S., Hasanova, Z., Kanagaraj, R., Chappidi, N., Altmannova, V., Menon, S., Sedlackova, H., Langhoff, J., Surendranath, K., Hühn, D., Bhowmick, R., Marini, V., Ferrari, S., Hickson, I. D., Krejci, L., & Janscak, P. (2017). RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Molecular Cell, 66(5), 658-671.e8. https://doi.org/10.1016/j.molcel.2017.05.006
Abstract
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Abstract
The MUS81-EME1 endonuclease cleaves late replication intermediates at common fragile sites (CFSs) during early mitosis to trigger DNA-repair synthesis that ensures faithful chromosome segregation. Here, we show that these DNA transactions are promoted by RECQ5 DNA helicase in a manner dependent on its Ser727 phosphorylation by CDK1. Upon replication stress, RECQ5 associates with CFSs in early mitosis through its physical interaction with MUS81 and promotes MUS81-dependent mitotic DNA synthesis. RECQ5 depletion or mutational inactivati
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- Di Marco, Stefano
- Hasanova, Zdenka
- Kanagaraj, Radhakrishnan
- Chappidi, Nagaraja
- Altmannova, Veronika
- Menon, Shruti
- Sedlackova, Hana
- Langhoff, Jana
- Surendranath, Kalpana
- Hühn, Daniela
- Bhowmick, Rahul
- Marini, Victoria
- Ferrari, Stefano
- Hickson, Ian D
- Krejci, Lumir
- Janscak, Pavel
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Di Marco, S., Hasanova, Z., Kanagaraj, R., Chappidi, N., Altmannova, V., Menon, S., Sedlackova, H., Langhoff, J., Surendranath, K., Hühn, D., Bhowmick, R., Marini, V., Ferrari, S., Hickson, I. D., Krejci, L., & Janscak, P. (2017). RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Molecular Cell, 66(5), 658-671.e8. https://doi.org/10.1016/j.molcel.2017.05.006
