Publication: Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation
Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation
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Jayakumar, P., Figueiredo, A. R. T., & Kümmerli, R. (2022). Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation. MSystems, 7(5), e0035422. https://doi.org/10.1128/msystems.00354-22
Abstract
Abstract
Abstract
Pseudomonas aeruginosa populations evolving in cystic fibrosis lungs, animal hosts, natural environments and in vitro undergo extensive genetic adaption and diversification. A common mutational target is the quorum sensing (QS) system, a three-unit regulatory system that controls the expression of virulence factors and secreted public goods. Three evolutionary scenarios have been advocated to explain selection for QS mutants: (i) disuse of the regulon, (ii) cheating through the exploitation of public goods, or (ii) modulation of the Q
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- Jayakumar, Priyanikha
- Figueiredo, Alexandre R T
- Kümmerli, Rolf
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Citations
Jayakumar, P., Figueiredo, A. R. T., & Kümmerli, R. (2022). Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation. MSystems, 7(5), e0035422. https://doi.org/10.1128/msystems.00354-22
