Publication: Experimental verification of a traceback phenomenon in prion infection
Experimental verification of a traceback phenomenon in prion infection
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Kobayashi, A., Sakuma, N., Matsuura, Y., Mohri, S., Aguzzi, A., & Kitamoto, T. (2010). Experimental verification of a traceback phenomenon in prion infection. Journal of Virology, 84(7), 3230–3238. https://doi.org/10.1128/JVI.02387-09
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The clinicopathological phenotypes of sporadic Creutzfeldt-Jakob disease (sCJD) correlate with the allelotypes (M or V) of the polymorphic codon 129 of the human prion protein (PrP) gene and the electrophoretic mobility patterns of abnormal prion protein (PrP(Sc)). Transmission of sCJD prions to mice expressing human PrP with a heterologous genotype (referred to as cross-sequence transmission) results in prolonged incubation periods. We previously reported that cross-sequence transmission can generate a new prion strain with unique tr
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- Kobayashi, A
- Sakuma, N
- Matsuura, Y
- Mohri, S
- Kitamoto, T
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Kobayashi, A., Sakuma, N., Matsuura, Y., Mohri, S., Aguzzi, A., & Kitamoto, T. (2010). Experimental verification of a traceback phenomenon in prion infection. Journal of Virology, 84(7), 3230–3238. https://doi.org/10.1128/JVI.02387-09
