Publication: The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport
The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport
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Wang, I.-H., Burckhardt, C. J., Yakimovich, A., Morf, M. K., & Greber, U. F. (2017). The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport. Journal of Cell Science, 130(13), 2185–2195. https://doi.org/10.1242/jcs.203794
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Transport of large cargo through the cytoplasm requires motor proteins and polarized filaments. Viruses that replicate in the nucleus of post-mitotic cells use microtubules and the dynein/dynactin motor to traffic to the nuclear membrane, and deliver their genome through nuclear pore complexes (NPCs) into the nucleus. How virus particles (virions) or cellular cargo are transferred from microtubules to the NPC is unknown. Here, we analyzed trafficking of incoming cytoplasmic adenoviruses by single particle tracking and super-resolution
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- Wang, I-Hsuan
- Burckhardt, Christoph J
- Yakimovich, Artur
- Morf, Matthias K
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Wang, I.-H., Burckhardt, C. J., Yakimovich, A., Morf, M. K., & Greber, U. F. (2017). The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport. Journal of Cell Science, 130(13), 2185–2195. https://doi.org/10.1242/jcs.203794
