Publication: Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS‐ICOSL interaction
Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS‐ICOSL interaction
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Fan, X., Xu, Z., Li, C., Zhang, H., Peng, Y., He, B., Liu, X., Chen, D., Chen, D., Akdis, C. A., & Fu, Q. (2021). Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS‐ICOSL interaction. Stem Cells, 39(7), 975–987. https://doi.org/10.1002/stem.3369
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Abstract
Group 2 innate lymphoid cells (ILC2s) are recognized as key controllers and effectors of type 2 inflammation. Mesenchymal stem cells (MSCs) have been shown to alleviate type 2 inflammation by modulating T lymphocyte subsets and decreasing TH 2 cytokine levels. However, the effects of MSCs on ILC2s have not been investigated. In this study, we investigated the potential immunomodulatory effects of MSCs on ILC2s in peripheral blood mononuclear cells (PBMCs) from allergic rhinitis patients and healthy subjects. We further investigated th
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- Fan, Xingliang
- Xu, Zhi‐Bin
- Li, Cheng‐Lin
- Zhang, Hong‐Yu
- Peng, Ya‐Qi
- He, Bi‐Xin
- Liu, Xiao‐Qing
- Chen, De‐Hua
- Chen, Dong
- Akdis, Cezmi A
- Fu, Qing‐Ling
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Fan, X., Xu, Z., Li, C., Zhang, H., Peng, Y., He, B., Liu, X., Chen, D., Chen, D., Akdis, C. A., & Fu, Q. (2021). Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS‐ICOSL interaction. Stem Cells, 39(7), 975–987. https://doi.org/10.1002/stem.3369
